Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development

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Expression of the receptor tyrosine kinase genes, Ror1 and Ror2, during mouse development

In mammals, the Ror-family receptor tyrosine kinases consist of two structurally related proteins, Ror1 and Ror2, characterized by the extracellular Frizzled-like cysteine-rich domain and membrane proximal kringle domains. As an attempt to gain insights into their roles in mouse development, expression patterns of Ror1 and Ror2 during early embryogenesis were examined and compared. Interestingl...

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construction and stable expression of a truncated human receptor tyrosine kinase ror1 (ror1-ecd)

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Construction and Stable Expression of a Truncated Human Receptor Tyrosine Kinase Ror1 (Ror1-ECD)

Expression of receptor tyrosine kinase Ror1 in a wide variety of cancers has emerged as a new era focusing on targeting this receptor in cancer therapy. Our preliminary results indicate the presence of a truncated transcript of Ror1 in tumor cells. The truncated Ror1 encompasses extracellular and transmembrane domains, lacking catalytic kinase domain (Ror1-ECD). As enzyme activity is highly dep...

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Neurite extension in central neurons: a novel role for the receptor tyrosine kinases Ror1 and Ror2.

Neurite elongation and branching are key cellular events during brain development as they underlie the formation of a properly wired neuronal network. Here we report that the receptor tyrosine kinases Ror1 and Ror2 modulate the growth of neurites as well as their branching pattern in hippocampal neurons. Upon Ror1 or Ror2 suppression using antisense oligonucleotides or RNA interference (RNAi), ...

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ژورنال

عنوان ژورنال: Mechanisms of Development

سال: 2001

ISSN: 0925-4773

DOI: 10.1016/s0925-4773(01)00383-5